Journal article

Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review

Benjamin Kioussis, Camilla SL Tuttle, Daniel S Heard, Brian K Kennedy, Nicola T Lautenschlager, Andrea B Maier

AGEING RESEARCH REVIEWS | ELSEVIER IRELAND LTD | Published : 2021

Abstract

BACKGROUND: Dementia is a debilitating syndrome that significantly impacts individuals over the age of 65 years. There are currently no disease-modifying treatments for dementia. Impairment of nutrient sensing pathways has been implicated in the pathogenesis of dementia, and may offer a novel treatment approach for dementia. AIMS: This systematic review collates all available evidence for Food and Drug Administration (FDA)-approved therapeutics that modify nutrient sensing in the context of preventing cognitive decline or improving cognition in ageing, mild cognitive impairment (MCI), and dementia populations. METHODS: PubMed, Embase and Web of Science databases were searched using key searc..

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Grants

Awarded by National Institute on Aging of the National Institutes of Health


Funding Acknowledgements

This work was supported by the National Institute on Aging of the National Institutes of Health (Grant Numbers R21AG057917 and R01AG053297). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.