Journal article

Clinical seizure manifestations in the absence of synaptic connections

Emma Macdonald-Laurs, Catherine A Bailey, Sarah Barton, Joseph Yuan-Mou Yang, Simone Mandelstam, Duncan Macgregor, Paul J Lockhart, Richard J Leventer, Wirginia J Maixner, A Simon Harvey

EPILEPTIC DISORDERS | JOHN LIBBEY EUROTEXT LTD | Published : 2021

Abstract

We report a child with a history of temporal-parietal-occipital disconnection for epilepsy secondary to posterior quadrantic dysplasia who developed recurrent and prolonged bouts of distress and autonomic disturbance associated with EEG and PET evidence of status epilepticus confined to his disconnected cortex. These bouts were refractory to antiseizure medications but resolved following resection of the disconnected cortex. In the absence of synaptic connections, we hypothesise that his seizure-related symptoms were mediated either by neurochemical transmission in preserved vascular and lymphatic channels or by ephaptic transmission to trigeminal nerve fibres in overlying dura, producing sy..

View full abstract

Grants

Awarded by Australian Government National Health and Medical Research Council


Funding Acknowledgements

We are grateful for the support of the Australian Government National Health and Medical Research Council GNT1128933, the Murdoch Children's Research Institute, the Campbell Edwards Trust and the Brain Foundation and the Victorian Government Operational Infrastructure Support Program.