Journal article

Mucosal-Associated Invariant T Cell Effector Function Is an Intrinsic Cell Property That Can Be Augmented by the Metabolic Cofactor alpha-Ketoglutarate

Lauren J Howson, Jasmine Li, Anouk von Borstel, Adele Barugahare, Jeffrey YW Mak, David P Fairlie, James McCluskey, Stephen J Turner, Martin S Davey, Jamie Rossjohn

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2021

Abstract

Mucosal-associated invariant T (MAIT) cells are an innate-like population of unconventional T cells that respond rapidly to microbial metabolite Ags or cytokine stimulation. Because of this reactivity and surface expression of CD45RO+, CD45RA-, and CD127+, they are described as effector memory cells. Yet, there is heterogeneity in MAIT cell effector response. It is unclear what factors control MAIT cell effector capacity, whether it is fixed or can be modified and if this differs based on whether activation is TCR dependent or independent. To address this, we have taken a systematic approach to examine human MAIT cell effector capacity across healthy individuals in response to ligand and cyt..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Australian Research Council (ARC)


Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

This work was supported by a program grant from the National Health and Medical Research Council of Australia (NHMRC) (1013667 and 1016629) and the Australian Research Council (ARC) (CE140100011); D.P.F. is supported by a NHMRC Senior Principal Research Fellowship (1117766); M.S.D. is supported by an ARC Discovery Early Career Researcher Award Fellowship; J.R. is supported by an Australian ARC Laureate Fellowship.