Journal article

Exploratory models comparing ethiodized oil-glue and gold fiducials for bladder radiotherapy image-guidance.

Daryl Lim Joon, Alexandra Berlangieri, Benjamin Harris, Mark Tacey, Rachel O'Meara, Brent Pitt, Angela Viotto, Kerryn Brown, Michal Schneider, Nathan Lawrentschuk, Shomik Sengupta, Colleen Berry, Trish Jenkins, Michael Chao, Morikatsu Wada, Farshad Foroudi, Vincent Khoo

Phys Imaging Radiat Oncol | Published : 2021

Abstract

Background and purpose: Image-guidance with fiducials has been shown to improve pelvic radiotherapy outcome. However, bladder fiducials using ethiodized oil (EO) alone can disperse widely, and gold causes Computed Tomography scan (CT) metal artifacts. The study's purpose was to investigate the ability to deliver EO-tissue glue fiducials and compare them to gold for bladder radiotherapy image guidance. Materials and methods: A fluid-filled porcine bladder model was used to assess the ability to cystoscopically inject visible EO glue fiducials into the submucosa. We then transferred the bladders into a porcine pelvis for imaging and compared them to gold fiducials using CT, Cone Beam CT (CBCT)..

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