Journal article

Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis

Israa Alfares, Muhammad Shahid Javaid, Zhibin Chen, Alison Anderson, Ana Antonic-Baker, Patrick Kwan

CNS DRUGS | ADIS INT LTD | Published : 2021


BACKGROUND: Cutaneous adverse drug reactions (cADRs) are one of the most common, severe, and life-threatening types of adverse reactions following treatment with antiseizure medications (ASMs). Some studies have reported a higher incidence of ASM-induced cADRs in females than in males. OBJECTIVE: This study sought to perform a systematic review, meta-analysis, and meta-regression to compare the ASM cADR risks between females and males. METHODS: We searched the literature using three databases (EMBASE, PubMed, and Web of Science) between October 1998 and November 2018, later updated to October 2019. Studies were included in the meta-analysis if they met the following criteria: (1) observation..

View full abstract


Awarded by Medical Research Future Fund Fellowship

Funding Acknowledgements

No specific funding has been received for the conduct of this study and/or preparation of this manuscript. Israa Alfares was supported as a domestic graduate student by the University of Melbourne and in collaboration with Melbourne Brain Centre at Royal Melbourne Hospital. Muhammad Shahid Javaid is supported by a Monash Graduate Scholarship and Monash International Tuition Scholarship. Zhibin Chen is supported by the NHMRC Early Career Fellowship. Patrick Kwan is supported by a Medical Research Future Fund Fellowship (MRF1136427).