Journal article
Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis
I Alfares, MS Javaid, Z Chen, A Anderson, A Antonic-Baker, P Kwan
CNS Drugs | Published : 2021
Abstract
Background: Cutaneous adverse drug reactions (cADRs) are one of the most common, severe, and life-threatening types of adverse reactions following treatment with antiseizure medications (ASMs). Some studies have reported a higher incidence of ASM-induced cADRs in females than in males. Objective: This study sought to perform a systematic review, meta-analysis, and meta-regression to compare the ASM cADR risks between females and males. Methods: We searched the literature using three databases (EMBASE, PubMed, and Web of Science) between October 1998 and November 2018, later updated to October 2019. Studies were included in the meta-analysis if they met the following criteria: (1) observation..
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Awarded by UCB Pharma
Funding Acknowledgements
No specific funding has been received for the conduct of this study and/or preparation of this manuscript. Israa Alfares was supported as a domestic graduate student by the University of Melbourne and in collaboration with Melbourne Brain Centre at Royal Melbourne Hospital. Muhammad Shahid Javaid is supported by a Monash Graduate Scholarship and Monash International Tuition Scholarship. Zhibin Chen is supported by the NHMRC Early Career Fellowship. Patrick Kwan is supported by a Medical Research Future Fund Fellowship (MRF1136427).