Phytochemical Profiling and Biological Activity of the Australian Carnivorous Plant, Drosera magna
Edward Owen Norman, Hayden Tuohey, David Pizzi, Milane Saidah, Rachael Bell, Robert Brkljaca, Jonathan M White, Robin B Gasser, Aya C Taki, Sylvia Urban
JOURNAL OF NATURAL PRODUCTS | AMER CHEMICAL SOC | Published : 2021
Phytochemical profiling was undertaken on the crude extracts of Drosera magna to determine the nature of the chemical constituents present. In total, three new flavonol diglycosides (1-3), one new flavan-3-ol glycoside (4), and 12 previously reported compounds of the flavonol (5, 9), flavan-3-ol (15), flavanone (8), 1,4-napthoquinone (6, 7, 13, 14), 2,3-dehydroxynapthalene-1,4-dione (10-12), and phenolic acid (16) structure classes were isolated and identified. Compounds 1-9, 13, 17, and 18 were assessed for antimicrobial activity, with compounds 6, 7, 8, and 9 showing significant activity. Compounds 1, 2, and 6 were also evaluated for anthelmintic activity against larval forms of Hemonchus ..View full abstract
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Awarded by Australian Research Council (ARC)
Awarded by ARC LIEF Scheme
The antimicrobial screening performed by CO-ADD (The Community for Antimicrobial Drug Discovery) was funded by the Wellcome Trust (UK) and The University of Queensland (Australia). E.O.N. would like to acknowledge the financial support awarded under the Research Stipend Scholarship (RSS) scheme provided by the Australian Government via RMIT University. The anthelmintic discovery project was funded by Yourgene Health Singapore Pty. Ltd. and the Australian Research Council (ARC Grant number LP160100058) (R.B.G.). J.M.W. acknowledges funding from the ARC LIEF Scheme (grant number LE170100065).