Journal article

5-HT containing enteroendocrine cells characterised by morphologies, patterns of hormone co-expression, and relationships with nerve fibres in the mouse gastrointestinal tract

Ada Koo, Linda J Fothergill, Hirofumi Kuramoto, John B Furness

HISTOCHEMISTRY AND CELL BIOLOGY | SPRINGER | Published : 2021

Abstract

5-HT containing enteroendocrine cells (EEC), the most abundant type of EEC in the gut, regulate many functions including motility, secretion and inflammatory responses. We examined the morphologies of 5-HT cells from stomach to rectum, patterns of hormone co-expression in the stomach and colon, and the relationship of 5-HT cells with nerve fibres. We also reviewed some of the relevant literature. The morphologies of 5-HT cells were distinct, depending on their location in the gut. A noticeable feature of some 5-HT cells in the antrum and colon was their long basal processes, which resembled processes of neurons, whereas 5-HT cells in the small intestinal mucosa lacked basal processes. In the..

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Grants

Funding Acknowledgements

This work was funded by the host laboratory. Ada Koo was in receipt of a Melbourne Research Scholarship awarded by the University of Melbourne.