Journal article

Transcriptomic Analysis of Long-Term Protective Immunity Induced by Vaccination With Mycoplasma gallisepticum Strain ts-304

Sathya N Kulappu Arachchige, Neil D Young, Anna Kanci Condello, Oluwadamilola S Omotainse, Amir H Noormohammadi, Nadeeka K Wawegama, Glenn F Browning

FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

Live attenuated vaccines are commonly used to control Mycoplasma gallisepticum infections in chickens. M. gallisepticum ts-304 is a novel live attenuated vaccine strain that has been shown to be safe and effective. In this study, the transcriptional profiles of genes in the tracheal mucosa in chickens challenged with the M. gallisepticum wild-type strain Ap3AS at 57 weeks after vaccination with ts-304 were explored and compared with the profiles of unvaccinated chickens that had been challenged with strain Ap3AS, unvaccinated and unchallenged chickens, and vaccinated but unchallenged chickens. At two weeks after challenge, pair-wise comparisons of transcription in vaccinated-only, vaccinated..

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Grants

Awarded by Australian Research Council


Funding Acknowledgements

This study was supported by the Australian Research Council through Linkage Project grant LP160101105 in partnership with Bioproperties Pty. Ltd.