Journal article

HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

Selena Alonso, Marta Vidal, Gemma Ruiz-Olalla, Raquel Gonzalez, Chenjerai Jairoce, M Nelia Manaca, Miquel Vazquez-Santiago, Reyes Balcells, Anifa Vala, Maria Ruperez, Pau Cistero, Laura Fuente-Soro, Evelina Angov, Ross L Coppel, Benoit Gamain, David Cavanagh, James G Beeson, Arsenio Nhacolo, Esperanca Sevene, John J Aponte Show all

Journal of Infection | W B SAUNDERS CO LTD | Published : 2021

Abstract

OBJECTIVES: Maternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses. METHODS: In a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens: Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (E..

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Grants

Awarded by European and Developing Countries Clinical Trials Partnership (EDCTP)


Awarded by Instituto de Salud Carlos III


Awarded by MINECO


Awarded by Department d'Universitats i Recerca de la Generalitat de Catalunya


Awarded by Department of Health, Catalan Government


Awarded by Spanish Ministry of Science and Innovation through the "Centro de Excelencia Severo Ochoa 2019-2023" Program


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This study was supported by the European and Developing Countries Clinical Trials Partnership (EDCTP; IP.20 07.31080.002); the Malaria in Pregnancy Consortium, which is funded by a grant from the Bill and Melinda Gates Foundation to the Liverpool School of Tropical Medicine; and the Instituto de Salud Carlos III (PI08/0564). The Centro de Investigacao em Saude da Manhica receives core support from the Spanish Agency for International Cooperation and Development (AECID). The study received funds from MINECO (SAF20 08-00743, RYC-20 08-02631 to C.D.), from Instituto de Salud Carlos III (PS09/01113, PI13/01478 to A. Mayor) and the Department d'Universitats i Recerca de la Generalitat de Catalunya (AGAUR; 2017SGR664to A.M., 2014SGR991 to C.D.). GM had the support of the Department of Health, Catalan Government (SLT0 06/17/00109). This research is part of the ISGlobal Program on the Molecular Mechanisms of Malaria which is partially supported by the Fundacion Ramon Areces and we acknowledge support from the Spanish Ministry of Science and Innovation through the "Centro de Excelencia Severo Ochoa 2019-2023" Program (CEX20180 00806-S), and support from the Generalitat de Catalunya through the CERCA Program. JGB is supported by the National Health and Medical Research Council of Australia (Investigator Grant 1173046).