Journal article

Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting

Michael E Nakai, Joshua Denham, Priscilla R Prestes, Nina Eikelis, Elisabeth A Lambert, Nora E Straznicky, Markus P Schlaich, Murray D Esler, Brendan J O'Brien, Fadi J Charchar, Gavin W Lambert, Francine Z Marques

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2021

Abstract

Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in maladaptive remodelling of the heart and has been associated with renal injury. While lifestyle factors such as diet and exercise are known to attenuate low-grade inflammation, their ability to modulate plasma LCN2 levels is unknown. Forty-eight endurance athletes and 52 controls (18-55 years) underwent measurement for various cardiovascular health indicators, along with plasma LCN2 concentration. No significant difference in LCN2 concentration was seen between..

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University of Melbourne Researchers