Journal article

Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease: A Meta-Analysis of Mood Effects

Tomas Cartmill, David Skvarc, Richard Bittar, Jane McGillivray, Michael Berk, Linda K Byrne

NEUROPSYCHOLOGY REVIEW | SPRINGER | Published : 2021

Abstract

This meta-analysis examines mood changes after bilateral subthalamic deep brain stimulation (STN-DBS) in patients with Parkinson's disease (PD). Deep brain stimulation improves motor outcomes in Parkinson's disease but there appears to be conflicting reports as to subsequent mood outcomes. Pubmed, PsychINFO and SCOPUS were searched for studies assessing mood outcomes in PD patients who had undergone STN-DBS published between January 2003 and the end of January 2019. Random effects meta-analyses were conducted for all outcome groups with at least two studies homogenous in design and measure. Forty-eight studies, providing data on negative moods (such as depression, anxiety, apathy, and anger)..

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University of Melbourne Researchers

Grants

Awarded by National Health & Medical Research Council (NHMRC) Senior Principal Research Fellowship


Funding Acknowledgements

MB is supported by a National Health & Medical Research Council (NHMRC) Senior Principal Research Fellowship (1059660).