Energy-Based Modeling of the Feedback Control of Biomolecular Systems With Cyclic Flow Modulation
Peter J Gawthrop
IEEE TRANSACTIONS ON NANOBIOSCIENCE | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2021
Energy-based modelling brings engineering insight to the understanding of biomolecular systems. It is shown how well-established control engineering concepts, such as loop-gain, arise from energy feedback loops and are therefore amenable to control engineering insight. In particular, a novel method is introduced to allow the transfer function based approach of classical linear control to be utilised in the analysis of feedback systems modelled by network thermodynamics and thus amalgamate energy-based modelling with control systems analysis. The approach is illustrated using a class of metabolic cycles with activation and inhibition leading to the concept of Cyclic Flow Modulation.
The author would like to thank the Melbourne School of Engineering for its support via a Professorial Fellowship, and Edmund Crampin and Michael Pan for their help, advice, and encouragement. The suggestions of anonymous reviewers were instrumental in improving this paper.