Journal article

Altered immune cell profiles and impaired CD4 T-cell activation in single and multi-food allergic adolescents

Melanie R Neeland, Sandra Andorf, Thanh D Dang, Vicki L McWilliam, Kirsten P Perrett, Jennifer J Koplin, Richard Saffery

CLINICAL AND EXPERIMENTAL ALLERGY | WILEY | Published : 2021

Abstract

BACKGROUND: Approximately 5% of adolescents have a food allergy, with peanut and tree nut allergies the most common. Having two or more food allergies in adolescence also doubles the risk of any adverse food reaction, and is associated with increased dietary and social burden. Investigations of immune function in persistently food allergic children are rare. OBJECTIVE: In the present study, we aimed to investigate the immune mechanisms that underlie food allergy in adolescence. METHODS: We used high-dimensional flow cytometry, unsupervised computational analysis and functional studies to comprehensively phenotype a range of non-antigen-specific immune parameters in a group of well-characteri..

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