Journal article

Identification and Characterisation of cis-Regulatory Elements Upstream of the Human Receptor Tyrosine Kinase Gene MERTK

Alexander D Walsh, Laura J Johnson, Alexandra J Harvey, Trevor J Kilpatrick, Michele D Binder

Brain Plasticity | IOS Press | Published : 2020

Abstract

MERTK encodes a receptor tyrosine kinase that regulates immune homeostasis via phagocytosis of apoptotic cells and cytokine-mediated immunosuppression. MERTK is highly expressed in the central nervous system (CNS), specifically in myeloid derived innate immune cells and its dysregulation is implicated in CNS pathologies including the autoimmune disease multiple sclerosis (MS). While the cell types and tissues that express MERTK have been well described, the genetic elements that define the gene’s promoter and regulate specific transcription domains remain unknown. Here, we have cloned and characterised the 5’ upstream region of MERTK and identified both proximal and distal-acting DNA element..

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