Journal article

Testing the Independent and Joint Contribution of Exposure to Neurodevelopmental Adversity and Childhood Trauma to Risk of Psychotic Experiences in Adulthood

Yiwen Liu, Marina Mendonca, Mary Cannon, Peter B Jones, Glyn Lewis, Andrew Thompson, Stanley Zammit, Dieter Wolke



Exposure to neurodevelopmental adversity and childhood trauma are both independently associated with psychosis. However, there is little research on the mechanism underlying their relationship with each other. The current study investigated both the independent and joint effects of neurodevelopmental adversity and childhood trauma to better understand the etiology of psychosis. A large population-based cohort (N = 3514) followed from birth was assessed on psychotic experiences (PE) at 24 years. Neurodevelopmental adversity included obstetric complications (birth weight, gestational age, in-utero influenza exposure, resuscitation) and developmental impairment (cognitive and motor impairments)..

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Awarded by European Research Council Consolidator Award

Awarded by European Unions Horizon 2020 research and innovation program (RECAP-preterm)

Awarded by NORFACE Network Dial program (PREMLIFE)

Awarded by Medical Research Council

Awarded by Wellcome Trust

Funding Acknowledgements

Data analysis and manuscript writing was funded by a PhD studentship at University of Warwick. Prof. Zammit is supported by NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and University of Bristol. Prof. Jones was supported by the NIHR Applied Research Collaboration East of England, and declare personal fees from Member Scientific Advisory Board (Janssen and Ricordati) outside the submitted work. Prof. Cannon is supported by a European Research Council Consolidator Award (724809, iHEAR), and Prof. Wolke by European Unions Horizon 2020 research and innovation program (RECAP-preterm) under grant agreement: 733280 and the NORFACE Network Dial program (PREMLIFE; grant 462-16-040). Collection of PE data was supported by Medical Research Council grant MR/M006727/1; Medical Research Council and Wellcome Trust (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp using support from 23andMe. A comprehensive list of grants is available at