Journal article
T9. CROSS-SECTIONAL ASSOCIATION OF MEMBRANE FATTY ACID COMPOSITION AND PSYCHOPATHOLOGY IN THE NEURAPRO-E STUDY
Maximus Berger, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam Schaefer, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian Hickie, Gregor Berger, Eric Chen, Lieuwe De Haan, Dorien Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Andrew Thompson, Alison Yung, G Paul Amminger
Schizophrenia Bulletin | Oxford University Press (OUP) | Published : 2018
Abstract
Converging evidence suggests that people at ultra-high risk (UHR) for psychosis have depleted levels of several fatty acids (FAs), and that changes in omega-3 (n-3) FA levels may indicate a higher risk for transition to psychosis. However, limited information is available on how FA deficiencies relate to psychopathology in individuals with UHR phenotypes. Here, we report the relationship between membrane FA levels and symptom severity in a study of individuals at UHR for psychosis. Data from 280 of 304 (92%) of participants of the NEURAPRO study, a multi-centre randomized-controlled trial of omega-3 fatty acids versus placebo, were used for the present analysis. All participants were aged be..
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