172 The Proprems Randomised Trial Investigating the Effects of Probiotics on Late Onset Sepsis in Very Preterm Infants

Abstract

Late onset sepsis (LOS) frequently complicates prematurity, and is associated with increased mortality and morbidity. Whilst probiotic supplementation in preterm infants reduces mortality and necrotising enterocolitis (NEC), the effect on LOS in the most vulnerable preterms is unknown. To determine the effects of probiotic supplementation in very preterm infants. A multi-centred, double-blinded, placebo-controlled, randomised controlled trial in very preterm infants born < 32 weeks’ gestation weighing < 1500g, supplemented daily with either a probiotic combination (Bifidobacterium infantis, Streptococcus thermophiles and Bifidobacterium lactis 1 x 109 total organisms) or placebo (multodextri..