Journal article

SOCS3 Regulates Th1 Dependent Acute Graft-Versus Host Disease

Kelli PA MacDonald, Rachel D Kuns, Alistair LJ Don, Stuart D Olver, Neil C Raffelt, Kate A Markey, Warren Alexander, Andrew W Roberts, Geoff R Hill

Blood | American Society of Hematology | Published : 2008


Abstract G-CSF mobilized peripheral blood has emerged as the dominant source of stem cells for allogeneic stem cell transplantation. G-CSF modulates T cell function and Suppressor of Cytokine Signaling-3 (SOCS3) is the major regulator of signaling by this cytokine, although the downstream effects in vivo remain unclear. We have therefore examined the effect of SOCS3 in the well established B6 → B6D2F1 murine model of acute GVHD directed to major histocompatibility antigens. Using SOCS3−/Δvav mice in which SOCS3 deficiency is restricted to the haematopoietic compartment we transplanted splenocytes from G-CSF mobilized wild-type (WT) or SOCS3−/Δvav donors and demonstrated that t..

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University of Melbourne Researchers