Journal article

Platelet Death.

Emma C Josefsson, Simone Schoenwaelder, Michael White, Matthew Goschnick, Andrew W Roberts, Kylie D Mason, Shaun Jackson, David C Huang, Benjamin T Kile

Blood | American Society of Hematology | Published : 2008

Abstract

Abstract Human platelets exhibit a circulating lifespan of ~10 days, mouse platelets ~5 days. This finite existence is circumscribed by members of the Bcl-2 family of proteins, which control the intrinsic apoptosis pathway. Pro-survival Bcl-xL is the critical regulator of platelet lifespan, functioning to keep pro-death Bak and Bax in check, thereby maintaining platelet viability. After 5–10 days in the circulation, platelets not consumed in hemostatic processes initiate a Bak and Bax-dependent cell death program and clearance from the bloodstream. Mutations in Bcl-xL reduce platelet lifespan in a dose-dependent fashion, while deletion of Bak and Bax extend it. Studies with th..

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University of Melbourne Researchers