Journal article

Uncovering the Bone-Muscle Interaction and Its Implications for the Health and Function of Older Adults (the Wellderly Project): Protocol for a Randomized Controlled Crossover Trial

Cassandra Smith, Xuzhu Lin, David Scott, Tara C Brennan-Speranza, Ahmed Al Saedi, Alba Moreno-Asso, Mary Woessner, Ebrahim Bani Hassan, Nir Eynon, Gustavo Duque, Itamar Levinger



BACKGROUND: Bone and muscle are closely linked anatomically, biochemically, and metabolically. Acute exercise affects both bone and muscle, implying a crosstalk between the two systems. However, how these two systems communicate is still largely unknown. We will explore the role of undercarboxylated osteocalcin (ucOC) in this crosstalk. ucOC is involved in glucose metabolism and has a potential role in muscle maintenance and metabolism. OBJECTIVE: The proposed trial will determine if circulating ucOC levels in older adults at baseline and following acute exercise are associated with parameters of muscle function and if the ucOC response to exercise varies between older adults with low muscle..

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Funding Acknowledgements

This work is supported by research funds of the primary investigators, IL and GD, and the PhD (Doctor of Philosophy) funds of CS. This trial has been awarded the Tom Penrose Community Service Award from Exercise and Sport Science Australia, a seed grant from AIMSS, and a Diabetes Australia Research Program Grant from Diabetes Australia. The grants awarded to this trial did not have any role in or contribution to the design of the study and the collection, analysis, or interpretation of the data; the grants awarded to this trial will not contribute to the writing of any associated manuscripts.