Global coagulation assays in healthy controls: are there compensatory mechanisms within the coagulation system?
Hui Yin Lim, Brandon Lui, Mark Tacey, Carly Selan, Geoffrey Donnan, Louise M Burrell, Harshal Nandurkar, Prahlad Ho
JOURNAL OF THROMBOSIS AND THROMBOLYSIS | SPRINGER | Published : 2021
Global coagulation assays (GCAs) may provide a more comprehensive individual hemostatic profiling. We aim to evaluate GCAs (thromboelastography, thrombin generation) in healthy controls, and correlate results with age, gender, lipid status, tissue factor pathway inhibitor (TFPI) and P-selectin. Blood samples were collected from healthy controls (> 18 years of age) not taking anticoagulation or antiplatelet agents and without known cardiovascular disease. Thromboelastography (TEG) was performed on citrated whole blood while calibrated automated thrombogram (CAT), P-selectin (endothelial marker) and TFPI (principle inhibitor of tissue factor-initiated coagulation) were performed on platelet-po..View full abstract
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Dr Lim is a recipient of the co-funded National Health and Medical Research Council (NHMRC) postgraduate scholarship and Heart Foundation Health Professional Scholarship.