Journal article

Tenofovir disoproxil fumarate in pregnancy for prevention of mother to child transmission of hepatitis B in a rural setting on the Thailand-Myanmar border: a cost-effectiveness analysis

Marieke Bierhoff, Chaisiri Angkurawaranon, Marcus J Rijken, Kanlaya Sriprawa, Pachinee Kobphan, Francois N Nosten, Michele van Vugt, Rose McGready, Angela Devine



BACKGROUND: Hepatitis B Virus (HBV) is transmitted from mother to child which can be prevented via birth dose vaccine combined with three follow up hepatitis B vaccines, hepatitis B immunoglobulins (HBIG), and maternal antiviral treatment with Tenofovir Disoproxil Fumarate (TDF). This study evaluates the cost effectiveness of six strategies to prevent perinatal HBV transmission in a resource limited setting (RLS) on the Thailand-Myanmar border. METHODS: The cost effectiveness of six strategies was tested by a decision tree model in R. All strategies included birth and follow up vaccinations and compared cost per infection averted against two willingness to pay thresholds: one-half and one gr..

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Awarded by Wellcome-Trust Major Overseas Program in Southeast Asia

Funding Acknowledgements

The work is supported by the Wellcome-Trust Major Overseas Program in Southeast Asia [grant number: 106698/Z/14/Z] to Mahidol University Oxford Tropical Medicine Research Programme which directly supports FN and RM from Shoklo Malaria Research Unit. The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.