The function and composition of brain tissue derived exosomes in human Alzheimer’s disease

Abstract

AbstractBackgroundExosomes are extracellular vesicles (EVs) found in all bodily fluids. They carry the unique biological fingerprint of the parental cell they were released from, making them an ideal source of tissue and disease specific biomarkers and they are key players in cell‐to‐cell communication. Identification of brain derived exosomes (BDEs) in the periphery, for the purpose of AD diagnosis, requires knowledge of the composition of exosomes in the CNS. Moreover, an appreciation of the technical complexities associated with the isolation and characterisation of exosomes. We have taken a rigorous approach to the study of exosomes in AD frontal cortex. We have determined their Aβ and t..