Journal article
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice
F Vacante, J Rodor, MK Lalwani, AD Mahmoud, M Bennett, AL De Pace, E Miller, K Van Kuijk, J De Bruijn, M Gijbels, TC Williams, MB Clark, JP Scanlon, AC Doran, R Montgomery, DE Newby, M Giacca, D O'Carroll, PWF Hadoke, L Denby Show all
Circulation Research | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
Abstract
Rationale: In the microenvironment of atherosclerotic lesions, vascular smooth muscle cells (vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving this switch are not fully understood. Long noncoding RNAs (lncRNAs) are dysregulated during vascular pathology, but relatively little is known about their involvement in controlling vSMCs function. Cardiac mesoderm enhancer-associated noncoding RNA (CARMN) is a lncRNA located immediately upstream of the microRNAs-143 and-145 (miR-143 and miR-145), both involved in vSMCs function. Objective: We investigated the role of the lncRNA CARMN, independent from miR-143 and miR-145, as a potential regulator of vSMC phenot..
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Awarded by Horizon 2020
Funding Acknowledgements
This work is supported by the British Heart Foundation (BHF) Research Excellent Award (RE/18/5/34216), BHF Chair (CH/11/2/28733) and fellowship to F. Vacante (FS/18/10/33413), and a BHF programme Grant to A.H. Baker (BHF CVR grant [RM/17/3/33381]) and the European Research Council Advanced Grant VASMIR (RE7644) to A.H. Baker and Dutch heart foundation fellowship 2016T060 and a Leducq transatlantic network grant to J.C. Sluimer and BHF project grant to A.H. Baker and L. Denby. This project has also received funding from the European Union's Horizon 2020 Programme for Research and Innovation (825670). T.C. Williams is the recipient of a Wellcome Trust award (204802/Z/16/Z). Australian National Health and Medical Research Council Early Career Fellowship (APP1072662 to M.B. Clark).