The Truncated Form of Hoxa1 Regulates Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.
Jean Hendy, Stewart A Fabb, Meaghan Wall, Paul J Simmons, Lorraine J Gudas, Grant A McArthur, Louise E Purton
Blood | American Society of Hematology | Published : 2009
Abstract Abstract 3654 Poster Board III-590 Homeobox (Hox) genes have been shown to play critical roles in the regulation of hematopoiesis. Unlike most other Hox genes, Hoxa1 has two alternatively spliced transcripts: full-length Hoxa1 (Hoxa1-993) and truncated Hoxa1 (Hoxa1-399), which is similar to Hoxa1-993 but lacks the homeobox domain. Roles for either of these Hox transcripts in hematopoiesis have not yet been described, and the function of Hoxa1-399 in organogenesis remains largely unknown. We found that Hoxa1-993 is expressed most strongly in hematopoietic stem cells (HSCs), less in progenitor cells and is absent in mature cells. Hoxa1-399,..View full abstract