Autologous stem cell transplantation for untreated transformed indolent B-cell lymphoma in first remission: An international, multicenter propensity matched study.
Collin K Chin, Kenneth JC Lim, Katharine L Lewis, Preetesh Jain, Yun Qing, Lei Feng, Chan Cheah, John Francis Seymour, David Ritchie, Kate Burbury, Constantine Si Lun Tam, Nathan Hale Fowler, Luis Fayad, Jason Westin, Sattva Swarup Neelapu, Fredrick B Hagemeister, Felipe Samaniego, Christopher Flowers, Loretta J Nastoupil, Michael Dickinson
Journal of Clinical Oncology | American Society of Clinical Oncology (ASCO) | Published : 2020
8021 Background: Transformation of untreated indolent B-cell lymphoma (Tr-iNHL) is associated with poor outcomes. Current practices are extrapolated from prospective studies of de novo large B-cell lymphoma (DLBCL) or small retrospective studies. High dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) is used as consolidation in first remission (CR1) in some centers but the evidence-base is weak. Methods: CLL/SLL, MCL as primary diseases and non-DLBCL transformations were excluded. Propensity score analysis (PSM) using the “greedy match” algorithm was used to match the baseline covariates to adjust for potential selection bias. Landmark analysis was performed with time ..View full abstract