Integrating Newer Prognostic Factors in Evaluation of Previously Treated Patients with CLL Receiving Salvage Treatment.
Jerry D Henderson, Susan M O’Brien, Xuemei Wang, Stefan H Faderl, Alessandra Ferrajoli, Guillermo Garcia-Manero, Constantine S Tam, Jan A Burger, Lynne V Abruzzo, Ellen Schlette, Susan Lerner, Michael J Keating, William G Wierda
Blood | American Society of Hematology | Published : 2008
Abstract Identifying factors that independently correlate with important clinical endpoints is critical to evaluating patients (pts) with CLL, helping with treatment planning and providing insights into the fundamental biology of disease. CLL is typically a disease of multiple relapses with expected response to salvage treatment lower with subsequent salvage treatment and progressively shorter remission durations, usually despite escalating treatment intensity. The expectation for outcome in previously treated pts is lower than for untreated pts. Certain prognostic factors may emerge to be dominant over the clinical course of the disease. We evaluated 484 previously treated pt..View full abstract