Journal article

SPON1 Is Associated with Amyloid-beta and APOE epsilon 4-Related Cognitive Decline in Cognitively Normal Adults

Shane Fernandez, Samantha C Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Madeline Peretti, Hamid R Sohrabi, Yen Ying Lim, Michael Weinborn, David Ames, Colin L Masters, Ralph N Martins, Stephanie Rainey-Smith, Christopher C Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L Villemagne, Tenielle Porter, Simon M Laws



. Background: Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer's disease. Objective: The aim of this study was to assess whether the association was present in cognitively normal older adults. Methods: Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study. Results: No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE) ɛ4 and rs11023..

View full abstract


Awarded by Cooperative Research Centre (CRC) for Mental Health through the CRC Program, an Australian Government Initiative

Awarded by NHMRC

Funding Acknowledgements

Funding for the AIBL study was provided in part by the study partners [Commonwealth Scientific Industrial and research Organization (CSIRO), Edith Cowan University (ECU), Mental Health Research institute (MHRI), National Ageing Research Institute (NARI), Austin Health, CogState Ltd.]. The AIBL study has also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre (CRC) for Mental Health -funded through the CRC Program (Grant ID:20100104), an Australian Government Initiative. This specific study was also supported by NHMRC Project Grant funding (APP1161706) awarded to SML.