Journal article
The association between mesial temporal tau with age, cognition and neocortical tau in Aβ cognitively unimpaired individuals using MK‐6240
Natasha Krishnadas, Colin Groot, Vincent Dore, Samantha C Burnham, Kun Huang, Colin L Masters, Ralph N Martins, Paul T Maruff, David Ames, Jurgen Fripp, Pierrick Bourgeat, Anita MY Goh, Victor LL Villemagne, Christopher C Rowe
Alzheimer's & Dementia | Wiley | Published : 2020
DOI: 10.1002/alz.045713
Abstract
AbstractBackgroundIt has been proposed that tau deposition in the mesial temporal lobe (MTL) is an age‐related occurrence. We investigated the effects of high mesial temporal tau on age, cognition and neocortical tau in Aβ‐ cognitively unimpaired individuals (CU).Method187 Aβ‐ cognitively unimpaired older adults (≥60 years) from the AIBL cohort were included in this study. MK‐6240 retention was assessed in the amygdala, hippocampus, parahippocampus and entorhinal cortex and in a composite mesial temporal (Me) region. We assessed the association between regional and neocortical retention, age and cognition (MMSE, composite memory scores (CMS), composite non‐memory scores (CNMS) and the AIBL p..
View full abstract