Towards a universal cortical tau sampling mask

Abstract

AbstractBackgroundThe introduction of the A/T/(N) framework raised several issues regarding the definition of T+. In which region should tau scans be sampled? Based on which tracer? In this work, we developed a “universal” cortical tau mask derived from three major tau ligands for the AD continuum, over which several different global/regional sampling VOI or composites can be applied.Method221 healthy elderly controls (HC) and 67 Alzheimer’s disease (AD) patients underwent tau scans with either 18F‐AV1451 (HC=54/AD=24), 18F‐MK6240 (HC=157/AD=22) or 18F‐PI2620 (HC=10/AD=21). All HC were Ab‐ (<20CL) and all AD were Ab+(20CL). The tau scans were spatially normalized using CapAIBL and the cerebe..