Risk factors for falls in preclinical and prodromal Alzheimer’s disease and dementia due to Alzheimer’s disease: Findings from the Australian Imaging, Biomarker and Lifestyle study of ageing (AIBL)

Abstract

AbstractBackgroundLiterature suggests that preclinical Alzheimer’s disease (AD) is associated with increased falls risk1. Falls are a major cause of morbidity and mortality in older people, particularly people living with dementia. We aimed to identify factors associated with falls in older Australians with baseline Aβ PET imaging.MethodParticipants from the Australian Imaging, Biomarker and Lifestyle Study of Ageing (AIBL), with baseline 11C‐PiB PET and 18‐monthly review for 6 years, including self‐reported falls. Participants with severe illness, alcohol abuse and cerebrovascular disease were excluded. Multivariable logistic regression was used to identify factors associated with falls, in..