Journal article

The Role of the Glucocorticoid System in Anchorage-independence during Progression of Squamous Cell Carcinoma

David Kennedy, Massimo Pignatelli, Yazan Hassona, Stephen S Prime, Nicola Cirillo

American Journal of Oral Medicine | American Journal of Oral Medicine | Published : 2015

Abstract

Background: Topical and systemic corticosteroids are widely used for the treatment of mucocutaneous disorders including those with malignant potential. We have shown previously that normal keratinocytes regulate the local concentration of active steroids, as well as synthesize hydrocortisone de novo following stimulation with ACTH. The role of locally produced hydrocortisone in tumour progression is unclear. Objective: To examine the ability of endogenously-produced and exogenously-administered hydrocortisone on the capacity of human keratinocytes to promote the formation of anchorage-independent multicellular aggregates (MCAs) in vitro. Methods: The human keratinocyte cell line HaCaT deri..

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University of Melbourne Researchers

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