291. MicroRNAs in maternal circulation as predictors of preeclampsia at term

Abstract

Introduction MicroRNAs (miRs) are small RNA molecules involved in the negative regulation of genes, that are highly stable within the circulation. The FLAG study is a prospective collection of over 2000 maternal blood samples at 28 and 36 weeks gestation. 3.9% of FLAG patients developed preeclampsia(PE) after 36 weeks. Objectives/Hypothesis We hypothesise that circulating miRs will be dysregulated in the blood of women preceding diagnosis of PE. Our objective was to screen women at 36 weeks gestation to identify potential biomarkers of PE. Methods A panel of 41 miRs were selected for analysis: 32 were from the placental-specific C19MC cluster and 9 identified as previously associated with PE..