293. Preclinical assessment of new generation antiplatelet therapies to prevent preeclampsia

Abstract

Key pathophysiological steps in preeclampsia include 1) placental oxidative stress, 2) elevated sFlt1 and 3) endothelial dysfunction. While the antiplatelet drug aspirin has shown potential to prevent preeclampsia, its effectiveness remains limited. New generation antiplatelet drugs (Clopidogrel, Prasugrel and Ticagrelor) have distinct properties beyond antiplatelet actions (inflammation and endothelial dysfunction), thus may be more effective to prevent preeclampsia. We examined whether new generation antiplatelet drugs are better than aspirin at countering various pathophysiological steps in models of preeclampsia. Methods Primary human cytotrophoblast, placental explants and endothelial c..