43 New generation antiplatelet therapies to prevent preeclampsia

Abstract

IntroductionPreeclampsia is a serious complication of pregnancy. Responsible for thousands of maternal and fetal deaths worldwide, there is no cure. Key pathophysiological steps in preeclampsia include 1) placental damage and oxidative stress, 2) elevated sFlt1 and soluble endoglin (sEng) and 3) endothelial dysfunction. While the antiplatelet drug aspirin is used clinically to prevent preeclampsia, its effectiveness, if any, remains limited. New generation antiplatelet therapies (Clopidogrel, Prasugrel and Ticagrelor) have health benefits beyond anti-thrombus formation (they reduce oxidative damage, inflammation and endothelial dysfunction) and thus may be more effective to prevent preeclamp..