Differential SOD2 and GSTZ1 profiles contribute to contrasting dental pulp stem cell susceptibilities to oxidative damage and premature senescence
Nadia YA Alaidaroos, Amr Alraies, Rachel J Waddington, Alastair J Sloan, Ryan Moseley
STEM CELL RESEARCH & THERAPY | BMC | Published : 2021
BACKGROUND: Dental pulp stem cells (DPSCs) are increasingly being advocated as viable cell sources for regenerative medicine-based therapies. However, significant heterogeneity in DPSC expansion and multi-potency capabilities are well-established, attributed to contrasting telomere profiles and susceptibilities to replicative senescence. As DPSCs possess negligible human telomerase (hTERT) expression, we examined whether intrinsic differences in the susceptibilities of DPSC sub-populations to oxidative stress-induced biomolecular damage and premature senescence further contributed to this heterogeneity, via differential enzymic antioxidant capabilities between DPSCs. METHODS: DPSCs were isol..View full abstract
This study was supported by a PhD studentship awarded to Dr. Nadia Y.A. Alaidaroos by the Ministry of Defense, Directorate General of Armed Forces Medical Services, Saudi Arabia.