Clinical and immune effects of probiotic and peanut oral immunotherapy for treatment of peanut allergy

Abstract

Food allergen oral immunotherapy (OIT) is emerging as a potential treatment for food allergy. Probiotic and Peanut Oral Immunotherapy (PPOIT) showed effectiveness inducing non-responsiveness to peanut in the immediate post-treatment period. This doctoral thesis investigates the long-term clinical and immunologic effects of PPOIT in children with peanut allergy and the efficacy and tolerability of a modified PPOIT dose escalation schedule designed to improve treatment feasibility.