Journal article

Effect of intravenous alteplase on post-stroke depression in the WAKE UP trial

Alina Konigsberg, Susanne Sehner, Sonke Arlt, Bastian Cheng, Claus Z Simonsen, Florent Boutitie, Joaquin Serena, Vincent Thijs, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Christian Gerloff, Gotz Thomalla

EUROPEAN JOURNAL OF NEUROLOGY | WILEY | Published : 2021

Abstract

BACKGROUND AND PURPOSE: The aim was to study the effect of intravenous alteplase on the development of post-stroke depression (PSD) in acute stroke patients, and to identify predictors of PSD. METHODS: This post hoc analysis included patients with unknown onset stroke randomized to treatment with alteplase or placebo in the WAKE-UP trial (ClinicalTrials.gov number, NCT01525290), in whom a composite end-point of PSD was defined as a Beck Depression Inventory ≥10, medication with an antidepressant, or depression recorded as an adverse event. Multiple logistic regression was used to identify predictors of PSD at 90 days. Structural equation modelling was applied to assess the indirect effect of..

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