Journal article

Keeping your options open: insights from Dppa2/4 into how epigenetic priming factors promote cell plasticity

Melanie A Eckersley-Maslin

Biochemical Society Transactions | PORTLAND PRESS LTD | Published : 2020


The concept of cellular plasticity is particularly apt in early embryonic development, where there is a tug-of-war between the stability and flexibility of cell identity. This balance is controlled in part through epigenetic mechanisms. Epigenetic plasticity dictates how malleable cells are to change by adjusting the potential to initiate new transcriptional programmes. The higher the plasticity of a cell, the more readily it can adapt and change its identity in response to external stimuli such as differentiation cues. Epigenetic plasticity is regulated in part through the action of epigenetic priming factors which establish this permissive epigenetic landscape at genomic regulatory element..

View full abstract


Awarded by BBSRC Discovery Fellowship

Funding Acknowledgements

A special thank you goes to Aled Parry, Andrew Malcolm and Peter Rugg-Gunn for critical reading of the manuscript and helpful suggestions. Scientific illustrations were drawn in partnership with PTDesign. MAE-M is supported by a BBSRC Discovery Fellowship [BB/T009713/1].