Journal article

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition

Melanie A Eckersley-Maslin, Celia Alda-Catalinas, Wolf Reik

NATURE REVIEWS MOLECULAR CELL BIOLOGY | NATURE PUBLISHING GROUP | Published : 2018

Abstract

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling, genome spatial reorganization and substantial transcriptional changes. Key to these changes is the transition from the maternal environment of the oocyte to an embryonic-driven developmental expression programme, a process termed the maternal-to-zygotic transition (MZT). Zygotic genome activation occurs predominantly at the two-cell stage in mice and the eight-cell stage in humans, yet the dynamics of its control are still mostly obscure. In recent years, partly due to single-cell and low-cell number epigenomi..

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Grants

Awarded by BBSRC


Awarded by Wellcome Trust


Funding Acknowledgements

The authors thank W. Dean, C. Hanna, F. Santos, I. Herraez and T. Lohoff for careful reading of the manuscript. The authors apologize to all authors of studies they could not cite given the concise nature of this Review. M.A.E.-M. is supported by a Marie Sklodowska-Curie Individual Fellowship, and C.A.-C. is supported by a postgraduate award by the Biotechnology and Biological Sciences Research Council (BBSRC). The laboratory of W.R. is supported by the BBSRC (BB/K010867/1), the Wellcome Trust (095645/Z/11/Z), EU BLUEPRINT and EpiGeneSys.