Conference Proceedings
Folate and folic acid intake in relation to molecular subtypes of colorectal cancer; a pooled analysis of 7542 cases
Bethany Van Guelpen, Bjorn Gylling, Sophia Harlid, Anna Winkvist, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Andrew T Chan, Jenny Chang-Claude, Steven J Gallinger, Graham G Giles, Marc J Gunter, Michael Hoffmeister, Li Hsu, Mark A Jenkins, Roger L Milne, Polly A Newcomb, Shuji Ogino, John D Potter, Conghui Qu Show all
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2020
Abstract
Abstract Background: Higher folate intake has been reported to be associated with modestly lower risk of colorectal cancer, but the overall state of the evidence is inconclusive. Revisiting putative and established lifestyle-related risk factors from the perspective of intertumoral heterogeneity is warranted, as risk relationships for a molecular subtype may be attenuated toward the null when colorectal cancer is investigated as a single disease. Aim: To investigate folate and folic acid intakes in relation to the risk of molecular subtypes of colorectal cancer. Methods: We pooled individual-level observational data from 7542 colorectal cancer cas..
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