Subthreshold Nanosecond Laser in Age-Related Macular Degeneration: Observational Extension Study of the LEAD Clinical Trial.
Robyn H Guymer, Fred K Chen, Lauren AB Hodgson, Emily Caruso, Colin A Harper, Sanjeewa S Wickremashinghe, Amy C Cohn, Pyrawy Sivarajah, Nicole Tindill, Chi D Luu, Zhichao Wu, undefined LEAD Study Group
Ophthalmol Retina | Published : 2021
PURPOSE: To evaluate the long-term effect of subthreshold nanosecond laser (SNL) treatment on progression to late age-related macular degeneration (AMD). DESIGN: Observational extension study of a randomized, sham-controlled trial. PARTICIPANTS: Two hundred twelve participants with bilateral large drusen. METHODS: The Laser Intervention in the Early Stages of AMD (LEAD) study was a 36-month trial where participants were randomized to receive SNL or sham treatment in 1 eye at 6-monthly intervals up to 30 months. After the completion of the LEAD study, the 2 largest recruiting sites offered remaining participants an opportunity to enroll in a 24-month observational extension study. This study ..View full abstract