Journal article

Subthreshold Nanosecond Laser in Age-Related Macular Degeneration: Observational Extension Study to the LEAD Clinical Trial

Zhichao Wu, Fred Kuanfu Chen, Lauren AB Hodgson, Emily Caruso, Colin A Harper, Sanjeewa S Wickremashinghe, Amy C Cohn, Pyrawy Sivarajah, Nicole Tindill, Chi D Luu, Robyn H Guymer

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2021

Abstract

PURPOSE: To evaluate the long-term effect of subthreshold nanosecond laser (SNL) treatment on progression to late age-related macular degeneration (AMD). DESIGN: Observational extension study of a randomized, sham-controlled trial. PARTICIPANTS: Two hundred twelve participants with bilateral large drusen. METHODS: The Laser Intervention in the Early Stages of AMD (LEAD) study was a 36-month trial where participants were randomized to receive SNL or sham treatment in 1 eye at 6-monthly intervals up to 30 months. After the completion of the LEAD study, the 2 largest recruiting sites offered remaining participants an opportunity to enroll in a 24-month observational extension study. This study ..

View full abstract

Grants

Awarded by National Health & Medical Research Council of Australia


Funding Acknowledgements

Support National Health & Medical Research Council of Australia (project grant no.: APP1027624 [RHG andCDL], and fellowship grant no.: GNT1103013 (RHG), APP1104985 [ZW], GNT1054712 [FKC], MRF1142962[FKC] and GNT1128343 [SSW]).