Journal article

The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice

Rachel A Davey, Michele Clarke, Suzanne B Golub, Patricia K Russell, Jeffrey D Zajac

Journal of Endocrinology | BIOSCIENTIFICA LTD | Published : 2021

Abstract

The physiological role of calcitonin, and its receptor, the CTR (or Calcr), has long been debated. We previously provided the first evidence for a physiological role of the CTR to limit maternal bone loss during lactation in mice by a direct action on osteocytes to inhibit osteocytic osteolysis. We now extend these findings to show that CTR gene expression is upregulated two- to three-fold in whole bone of control mice at the end of pregnancy (E18) and lactation (P21) compared to virgin controls. This was associated with an increase in osteoclast activity evidenced by increases in osteoclast surface/bone surface and Dcstamp gene expression. To investigate the mechanism by which the CTR inhib..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This research was supported by the National Health and Medical Research Council of Australia (Project Grant APP1058189), The Sir Edward Dunlop Medical Research Foundation, The Austin Health Medical Research Foundation and a Les and Eva Erdi Research Grant.