Journal article
Glucose Control following Missed and Late Meal Boluses with a Medtronic Enhanced-Hybrid Closed-Loop (E-HCL) System
Melissa H Lee, Sara Vogrin, Barbora Paldus, Hannah Jones, Varuni R Obeyesekere, Catriona M Sims, Sue A Wyatt, Glenn M Ward, Sybil A Mcauley, Richard Macisaac, Balasubramanian Krishnamurthy, Vijaya Sundararajan, Jenkins Alicia, David N O'Neal
DIABETES | AMER DIABETES ASSOC | Published : 2019
DOI: 10.2337/db19-1037-P
Abstract
Background: A missed or late meal insulin bolus can impact glycemia in type 1 diabetes (T1D). Aim: To study glucose control after missed and late meal boluses in T1D adults using a prototype enhanced hybrid closed-loop (E-HCL) system (Medtronic) providing automated basal insulin and correction boluses. Methods: Twelve T1D adults (median HbA1c 6.8% [IQR 6.2-7.2] | 51mmol/mol [44-55] participated. After 1-week run-in at home in Open Loop, E-HCL was activated during 1-week supervised hotel phase followed by 3 weeks free-living at-home. Participants consumed a standardized 40g carbohydrate dinner in the supervised phase. Four hours of post-prandial glucose data foll..
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