Abstract 165: Predicting risk of colorectal cancer depending on tumor pathology features for first-degree relatives of persons with colorectal cancer.

Abstract

Abstract Background: We hypothesised that colorectal cancer (CRC) risk for relatives of persons diagnosed with CRC could be predicted by tumor molecular pathology features. Methods: We studied a cohort of 5200 first-degree relatives (2550 women) of 792 probands with an incident invasive CRC who were recruited to the Australasian Colorectal Cancer Family Registry via population cancer registries. We excluded 32 families that were known to be Lynch syndrome. For the probands, a standardised tumor morphology review had been conducted; BRAF V600E mutation testing had been performed; and the DNA mismatch repair (MMR) status was determined by microsatellite instabilit..