Conference Proceedings
Comparison of brain atrophy and cognitive performance in individuals with low and high cardiovascular risk: Data from the Diabetes and Dementia (D2) Study
Carolina Restrepo, Emilio Werden, Rebecca Singleton, Mohamed Salah Khlif, Laura J Bird, Elif Ekinci, Richard MacIsaac, Piyush Srivastava, Sheila Patel, Louise Burrell, Amy Brodtmann
Alzheimer's & Dementia | Wiley | Published : 2020
DOI: 10.1002/alz.039593
Abstract
AbstractBackgroundGrowing evidence suggests that increased cardiovascular risk might accelerate brain atrophy and cognitive decline. The aim of this analysis was to investigate associations between the Framingham Risk Score (FRS), brain volume and cognitive function in individuals with type 2 diabetes (T2DM) participating in the Diabetes‐and‐Dementia (D2) study.MethodNinety cognitively‐normal participants with T2DM completed neuropsychological assessments, health‐and‐lifestyle questionnaires, 24‐hour ambulatory blood pressure monitoring and a 3T‐MRI scan. FreeSurfer (version 6.0) was used to estimate total brain volume (TBV), mean cortical thickness and subcortical volumes, including the tha..
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