Cognitive and imaging impacts of left ventricular hypertrophy in people with type 2 diabetes

Abstract

AbstractBackgroundOlder adults with type 2 diabetes mellitus (T2DM) are at an increased risk of cognitive decline and dementia. Left ventricular hypertrophy (LVH) is prevalent in T2DM and is independently associated with cognitive decline. We conducted a study to establish whether T2DM patients with LVH have increased rates of brain atrophy and cognitive impairment.MethodsThirty‐seven cognitively healthy adults (50 years and older) with T2DM were divided into those with (n=13) and without (n=24) LVH. All participants completed neuropsychological assessments, health‐and‐lifestyle questionnaires, 24‐hour ambulatory blood pressure monitoring, an echocardiogram and a 3T‐MRI scan. FreeSurfer (ver..