Journal article

[187-POS]

Bihui Hu, Huishu Liu, Qian Huang, JinYing Yang, Yanmin Jiang, Junjie Bao, Shaun Patrick Brennecke

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health | Elsevier BV | Published : 2015

DOI: 10.1016/j.preghy.2014.10.193

Abstract

ObjectivesPreeclampsia (PE) is a severe complication of pregnancy characterized by an excessive maternal systemic inflammatory response with activation of the immune system. However, few therapeutic options exist aside from delivery. In treating variety of diseases, CsA exertits positive effects by immunosuppressive role. The aim of the study was to test the hypothesis that Cyclosporin A attenuate inflammatory response on a preeclampsia model.MethodsUsing a low dose of lipopolysaccharide (LPS, 1.0μg/kg) on gestational day (GD) 14 to induced preeclampsia (PE) rat model. CsA was administrated by 5mg/kg or 10mg/kg on day of 16, 17, 18 of pregnancy based on the PE model. Then we compared blood p..

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University of Melbourne Researchers

Keywords

Perinatal Period - Conditions Originating in Perinatal Period
3 Good Health and Well Being
Hypertension
2.1 Biological and Endogenous Factors
Pediatric Research Initiative
32 Biomedical and Clinical Sciences
Cardiovascular
Maternal Health
3202 Clinical Sciences
Women'S Health
Maternal Morbidity and Mortality
6.1 Pharmaceuticals
Contraception/reproduction