Journal article

Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases

Parsa Ravanfar, Samantha M Loi, Warda T Syeda, Tamsyn E Van Rheenen, Ashley I Bush, Patricia Desmond, Vanessa L Cropley, Darius JR Lane, Carlos M Opazo, Bradford A Moffat, Dennis Velakoulis, Christos Pantelis

FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2021

Abstract

Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new magnetic resonance imaging technique, quantitative susceptibility mapping (QSM), has enabled for the more comprehensive investigation of iron distribution in the brain. The aim of this systematic review was to provide a synthesis of the findings from existing QSM studies in neurodegenerative diseases. We identified 80 records by searching MEDLINE, Embase, Scopus, and PsycInfo databases. The disorders investigated in these studies included Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Wilson's disease, Huntington's disease, Friedreich's at..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship


Awarded by NHMRC L3 Investigator Grant


Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

The authors would like to thank Prof. Martha E. Shenton and Dr. Amanda E. Lyall (Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA) for their valuable contributions and feedback on the drafts of this manuscript. CP was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1105825), an NHMRC L3 Investigator Grant (1196508). AIB was supported by a NHMRC L3 Investigator Grant (1194028). VLC was supported by an Australian National Health and Medical Research Council EL2 Investigator Grant (1177370) and a University of Melbourne Dame Kate Campbell Fellowship. BAM holds a fellowship from the National Imaging Facility, funded by the Australian Government NCRIS program.